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Article

Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations.

PloS one - 25 Jul 2007

Johnson Jeffrey A, Li Jin-Fen, Wei Xierong, Lipscomb Jonathan, Bennett Diane, Brant Ashley, Cong Mian-Er, Spira Thomas, Shafer Robert W, Heneine Walid

Abstract excerpt

BACKGROUND: The success of antiretroviral therapy is known to be compromised by drug-resistant HIV-1 at frequencies detectable by conventional bulk sequencing. Currently, there is a need to assess the clinical consequences of low-frequency drug resistant variants occurring below the detection lim...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17653265
DOI: 10.1371/journal.pone.0000638
PMCID: PMC1919426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17653265-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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