Article
The polymorphisms of interleukin-10 gene influence the prognosis of patients with advanced melanoma.
Cancer genetics and cytogenetics - 1 Jul 2007
Vuoristo Meri-Sisko
Abstract excerpt
The interleukin-10 gene (IL-10) is polymorphic. The genotypes result in inter-individual differences in IL-10 production, which may play a role in the pathophysiology and the clinical course of melanoma and other cancers. We analyzed the frequency of the ATA haplotype formed by the alleles at -1082 (G/A), -819 (C/T), and -592 (C/A) at the promoter region of the IL-10 gene in patients with melanoma (n = 108) and...
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