Article
Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.
Genes and immunity - 1 Sept 2009
Schoof N, von Bonin F, König I R, Mössner R, Krüger U, Reich K, Berking C, Volkenandt M, Ziegler A, Böckmann L, Kuschal C, Thoms K-M, Kube D, Emmert S
Abstract excerpt
Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5'-flanking region in a hospital-based case-control study...
Read the complete abstract on PubMed