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Article

Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.

Human mutation - 1 Dec 2008

Li Chunying, Zhao Hui, Hu Zhibin, Liu Zhensheng, Wang Li-E, Gershenwald Jeffrey E, Prieto Victor G, Lee Jeffrey E, Duvic Madeleine, Grimm Elizabeth A, Wei Qingyi

Abstract excerpt

Caspase-8 (CASP8) and caspase-10 (CASP10) play key roles in regulating apoptosis, and their functional polymorphisms may alter apoptosis and cancer risk. However, no reported studies have investigated the association between such polymorphisms and the risk of cutaneous melanoma (CM). In a hospital-based study of 805 non-Hispanic white patients with CM and 835 cancer-free age-, sex-, and ethnicity-matched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18563783
DOI: 10.1002/humu.20803
PMCID: PMC2937220

Genes

CASP8
CASP10

Variants

rs1045485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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