Article
Influence of interleukin-10 genetic polymorphism on survival rates in melanoma patients with advanced disease.
Melanoma research - 1 Feb 2005
Alonso Rebeca, Suarez Ana, Castro Patricia, Lacave Angel J, Gutierrez Carmen
Abstract excerpt
Individual ability to produce interleukin-10 (IL-10) may be of relevance in the development and evolution of cutaneous melanoma, probably due to its immunosuppressor and anti-angiogenic properties. Single nucleotide polymorphisms at positions -1082 (G/A), -819 (C/T) and -592 (C/A) in the IL-10 gene promoter were analysed in 100 healthy individuals and 98 melanoma patients using fluorogenic hybridization-specific...
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