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Article

Investigation of alpha-synuclein fibril structure by site-directed spin labeling.

The Journal of biological chemistry - 24 Aug 2007

Chen Min, Margittai Martin, Chen Jeannie, Langen Ralf

Abstract excerpt

The misfolding and fibril formation of alpha-synuclein plays an important role in neurodegenerative diseases such as Parkinson disease. Here we used electron paramagnetic resonance spectroscopy, together with site-directed spin labeling, to investigate the structural features of alpha-synuclein fibrils. We generated fibrils from a total of 83 different spin-labeled derivatives and observed single-line,...

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Identifiers

PMID: 17573347
DOI: 10.1074/jbc.M700368200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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