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Article

Locally resolved membrane binding affinity of the N-terminus of α-synuclein.

Biochemistry - 15 May 2012

Robotta Marta, Hintze Christian, Schildknecht Stefan, Zijlstra Niels, Jüngst Christian, Karreman Christiaan, Huber Martina, Leist Marcel, Subramaniam Vinod, Drescher Malte

Abstract excerpt

α-Synuclein is abundantly present in Lewy bodies, characteristic of Parkinson's disease. Its exact physiological role has yet to be determined, but mitochondrial membrane binding is suspected to be a key aspect of its function. Electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling allowed for a locally resolved analysis of the protein-membrane binding affinity for artificial...

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PMID: 22494024
DOI: 10.1021/bi300357a

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