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Article

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.

PLoS genetics - 1 Jun 2007

Toivonen Janne M, Walker Glenda A, Martinez-Diaz Pedro, Bjedov Ivana, Driege Yasmine, Jacobs Howard T, Gems David, Partridge Linda

Abstract excerpt

To investigate whether alterations in mitochondrial metabolism affect longevity in Drosophila melanogaster, we studied lifespan in various single gene mutants, using inbred and outbred genetic backgrounds. As positive controls we included the two most intensively studied mutants of Indy, which encodes a Drosophila Krebs cycle intermediate transporter. It has been reported that flies heterozygous for these Indy...

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Identifiers

PMID: 17571923
DOI: 10.1371/journal.pgen.0030095
PMCID: PMC1892600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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