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Article

Support for Y-compensation of mother's curse affecting lifespan in Drosophila melanogaster.

Heredity - 1 Dec 2024

Nielsen Tobias Møgelvang, Baldwin Jaden, Danis Megan, Fedorka Kenneth M

Abstract excerpt

Mother's curse refers to male-biased deleterious mutations that may accumulate on mitochondria due to its strict maternal inheritance. If these mutations persist, males should ideally compensate through mutations on Y-chromosomes given its strict paternal inheritance. Previous work addressed this hypothesis by comparing coevolved and non-coevolved Y-mitochondria pairs placed alongside completely foreign autosomal...

Topics

Animals
Drosophila melanogaster
Male
Longevity
Mitochondria
Y Chromosome
Female
Mutation
Maternal Inheritance
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39369145
DOI: 10.1038/s41437-024-00726-w
PMCID: PMC11589675

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