Article
Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background.
Aging cell - 1 Apr 2003
Spencer Christine C, Howell Christine E, Wright Amber R, Promislow Daniel E L
Abstract excerpt
Molecular advances of the past decade have led to the discovery of a myriad of 'aging genes' (methuselah, Indy, InR, Chico, superoxide dismutase) that extend Drosophila lifespan by up to 85%. Despite this life extension, these mutants are no longer lived than at least some recently wild-caught strains. Typically, long-lived mutants are identified in relatively short-lived genetic backgrounds, and their effects...
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