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Article

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.

The Journal of biological chemistry - 5 Oct 2001

Schubert L A, Jeffery E, Zhang Y, Ramsdell F, Ziegler S F

Abstract excerpt

We have recently identified and cloned Foxp3, the gene defective in mice with the scurfy mutation. The immune dysregulation documented in these mice and in humans with mutations in the orthologous gene indicates that the foxp3 gene product, scurfin, is involved in the regulation of T cell activation and differentiation. The autoimmune state observed in these patients with the immune dysregulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11483607
DOI: 10.1074/jbc.M104521200

Genes

FOXP3
SFN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.PMID 11483607Read ↗

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