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Article

The X factor: skewing X inactivation towards cancer.

Cell - 29 Jun 2007

Medema René H, Burgering Boudewijn M Th

Abstract excerpt

Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.

Read the complete abstract on PubMed

Topics

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Share to Breast Neoplasms
Share to Cell Transformation, Neoplastic
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Gene Expression Regulation, Neoplastic

Share to Receptor, ErbB-2

Share to Tumor Suppressor Proteins

Share to X Chromosome Inactivation

Source

Identifiers

PMID: 17604714
DOI: 10.1016/j.cell.2007.06.008

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The X factor: skewing X inactivation towards cancer.PMID 17604714Read ↗

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.Semantic proximity Read ↗

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Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer CellsSemantic proximity Read ↗

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2Semantic proximity Read ↗

Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.Semantic proximity Read ↗

Heterozygous genetic variations of FOXP3 in Xp11.23 elevate breast cancer risk in Chinese population via skewed X-chromosome inactivation.Semantic proximity Read ↗

The dual role of the X‐linked FoxP3 gene in human cancersSemantic proximity Read ↗

Human FOXP3 and cancerSemantic proximity Read ↗

FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.Semantic proximity Read ↗

Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.Semantic proximity Read ↗

Foxp3 Expression in p53-dependent DNA Damage ResponsesSemantic proximity Read ↗

Towards gene therapy for IPEX syndrome.Semantic proximity Read ↗

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