Article
Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops.
PloS one - 1 Jan 2013
Sattin Giovanna, Artese Anna, Nadai Matteo, Costa Giosuè, Parrotta Lucia, Alcaro Stefano, Palumbo Manlio, Richter Sara N
Abstract excerpt
Telomeres are guanine-rich sequences that protect the ends of chromosomes. These regions can fold into G-quadruplex structures and their stabilization by G-quadruplex ligands has been employed as an anticancer strategy. Genetic analysis in human telomeres revealed extensive allelic variation restricted to loop bases, indicating that the variant telomeric sequences maintain the ability to fold into G-quadruplex....
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