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Article

miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4

29 Aug 2022

Abstract excerpt

Growing evidence indicates that transient receptor potential (TRP) channels contribute to different forms of pruritus. However, the endogenous mediators that cause itch through transient receptor potential channels signaling are poorly understood. In this study, we show that genetic deletion or pharmacological antagonism of TRPV4 attenuated itch in a mouse model of psoriasis induced by topical application of...

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Identifiers

PMID: 36049541
DOI: 10.1016/j.jid.2022.08.034

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