Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.

The EMBO journal - 1 Dec 1991

Herman P K, Stack J H, Emr S D

Abstract excerpt

The yeast VPS15 gene encodes a novel protein kinase homolog that is required for the sorting of soluble hydrolases to the yeast vacuole. In this study, we extend our previous mutational analysis of the VPS15 gene and show that alterations of specific Gps15p residues, that are highly conserved among all protein kinase molecules, result in the biological inactivation of Vps15p. Furthermore, we demonstrate here that...

Topics

Fungal Proteins
Genes, Fungal
Hydrolases
Mutagenesis, Site-Directed
Mutation
Myristic Acid
Myristic Acids
Phosphorylation
Plasmids
Precipitin Tests
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Temperature

Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 1756716
DOI: 10.1002/j.1460-2075.1991.tb04981.x
PMCID: PMC453153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1756716-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.PMID 1756716Read ↗

Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.Semantic proximity Read ↗

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.Semantic proximity Read ↗

The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases.Semantic proximity Read ↗

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.Semantic proximity Read ↗

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

Vps factors are required for efficient transcription elongation in budding yeast.Semantic proximity Read ↗

A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole.Semantic proximity Read ↗

Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.Semantic proximity Read ↗

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Semantic proximity Read ↗

A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.