Article
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.
The Journal of cell biology - 1 Apr 1995
Stack J H, DeWald D B, Takegawa K, Emr S D
Abstract excerpt
A membrane-associated complex composed of the Vps15 protein kinase and the Vps34 phosphatidylinositol 3-kinase (PtdIns 3-kinase) is essential for the delivery of proteins to the yeast vacuole. An active Vps15p is required for the recruitment of Vps34p to the membrane and subsequent stimulation of...
Topics
- Alleles
- Biological Transport
- Carboxypeptidases
- Cathepsin A
- Endosomal Sorting Complexes Required for Transport
- Enzyme Activation
- Genetic Complementation Test
- Mutation
- Phenotype
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Serine-Threonine Kinases