Article
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.
Cell - 20 May 1994
Marcusson E G, Horazdovsky B F, Cereghino J L, Gharakhanian E, Emr S D
Abstract excerpt
The S. cerevisiae VPS10 (vacuolar protein sorting) gene encodes a type I transmembrane protein of 1577 amino acids required for the sorting of the soluble vacuolar protein carboxypeptidase Y (CPY). Mutations in VPS10 result in the selective missorting and secretion of CPY; all other vacuolar prot...
Topics
- Amino Acid Sequence
- Carboxypeptidases
- Cathepsin A
- Cloning, Molecular
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Glycosylation
- Golgi Apparatus
- Membrane Proteins
- Models, Biological
- Molecular Sequence Data
- Mutation
- Receptors, Cell Surface
- Receptors, Cytoplasmic and Nuclear
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Analysis, DNA