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Article

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.

Cell - 20 May 1994

Marcusson E G, Horazdovsky B F, Cereghino J L, Gharakhanian E, Emr S D

Abstract excerpt

The S. cerevisiae VPS10 (vacuolar protein sorting) gene encodes a type I transmembrane protein of 1577 amino acids required for the sorting of the soluble vacuolar protein carboxypeptidase Y (CPY). Mutations in VPS10 result in the selective missorting and secretion of CPY; all other vacuolar proteins tested are delivered to the vacuole in vps10 mutants. Chemical cross-linking studies demonstrate that Vps10p and...

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Source

Identifiers

PMID: 8187177
DOI: 10.1016/0092-8674(94)90219-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.PMID 8187177Read ↗

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Semantic proximity Read ↗

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.Semantic proximity Read ↗

The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases.Semantic proximity Read ↗

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.Semantic proximity Read ↗

Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment.Semantic proximity Read ↗

Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment.Semantic proximity Read ↗

A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.Semantic proximity Read ↗

The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.Semantic proximity Read ↗

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.Semantic proximity Read ↗

A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins.Semantic proximity Read ↗

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