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Article

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.

European journal of cell biology - 1 Aug 1996

Chen Y J, Stevens T H

Abstract excerpt

To better understand the process of protein sorting to the yeast vacuole, the VPS8 gene was identified and characterized. VPS8 encodes a membrane-associated hydrophilic protein of 135 kDa (Vps8p), which is required for the accurate sorting of the vacuolar hydrolase, carboxypeptidase Y (CPY). vps8 mutant cells missort and secrete CPY as well as a second soluble vacuolar hydrolase, proteinase A. In vps8 mutants,...

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Source

Identifiers

PMID: 8864656

Genes

VPS8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.PMID 8864656Read ↗

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases.Semantic proximity Read ↗

The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.Semantic proximity Read ↗

Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.Semantic proximity Read ↗

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.Semantic proximity Read ↗

Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment.Semantic proximity Read ↗

Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p.Semantic proximity Read ↗

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A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins.Semantic proximity Read ↗

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.Semantic proximity Read ↗

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