Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases.

International journal of cancer - 1 Oct 2007

Loft Steffen, Svoboda Peter, Kasai Hiroshi, Tjønneland Anne, Møller Peter, Sørensen Mette, Overvad Kim, Autrup Herman, Raaschou-Nielsen Ole

Abstract excerpt

Nitrosamines are mainly mutagenic through methylation of DNA. 7-Methylguanine (m(7)Gua) is a product of base excision repair and spontaneous depurination of such lesions in DNA and a metabolite from RNA. Associations between urinary excretion of m(7)Gua and risk of lung cancer were examined in a population-based cohort of 25,717 men and 27,972 women aged 50-64 years. During 3-7 years follow-up 260 cases with lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glutathione S-Transferase pi
Share to Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine

Share to Linear Models

Share to Lung Neoplasms

Share to Multivariate Analysis

Share to Registries

Share to Smoking

Source

Identifiers

PMID: 17565746
DOI: 10.1002/ijc.22863

Genes

GSTM1
GSTM3
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases.PMID 17565746Read ↗

Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study.Semantic proximity Read ↗

Modification of urinary N7-methylguanine excretion in smokers by glutathione-S-transferase M1 polymorphism.Semantic proximity Read ↗

Lung cancer risk and variation in MGMT activity and sequence.Semantic proximity Read ↗

Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer.Semantic proximity Read ↗

Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells.Semantic proximity Read ↗

MTHFR polymorphisms, folate intake and carcinogen DNA adducts in the lung.Semantic proximity Read ↗

Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers.Semantic proximity Read ↗

Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers.Semantic proximity Read ↗

A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.Semantic proximity Read ↗

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.Semantic proximity Read ↗

[Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer].Semantic proximity Read ↗

One-Week Kava Dietary Supplementation Increases Both Urinary N- and O-Glucuronides of NNAL, a Lung Carcinogen Major Metabolite, among Smokers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.