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[Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer].

Journal of preventive medicine and public health = Yebang Uihakhoe chi - 1 Mar 2006

Lee Chul-Ho, Lee Kye Young, Choe Kang-Hyeon, Hong Yun-Chul, Noh Sung-Il, Eom Sang-Yong, Ko Young-Jun, Zhang Yan Wei, Yim Dong-Hyuk, Kang Jong-Won, Kim Heon, Kim Yong-Dae

Abstract excerpt

OBJECTIVES: Oxidative DNA damage is a known risk factor of lung cancer. The glutathione peroxidase (GPX) antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides plays a significant role in protecting cells from the oxidative stress induced by reactive oxygen species. The aim of this case-control study was to investigate effects of oxidative stress and genetic polymorphisms of the GPX1 genes and the...

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PMID: 16615267

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GPX1

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