Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers.

doi:10.1093/carcin/15.5.813

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Article

Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers.

Carcinogenesis - 1 May 1994

Hirvonen A, Nylund L, Kociba P, Husgafvel-Pursiainen K, Vainio H

Abstract excerpt

We examined the genotypes of two polymorphic genes involved in the detoxification of several mutagenic and carcinogenic compounds in relation to tobacco smoking-associated urinary mutagenicity. The genes studied were the glutathione S-transferase-encoding GSTM1 gene and acetyltransferase-encoding...

Topics

Arylamine N-Acetyltransferase
Biotransformation
Carcinogens
Female
Genotype
Glutathione Transferase
Humans
Male
Middle Aged
Mutagenicity Tests
Mutagens
Smoking

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