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Article

Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells.

Mutation research - 11 Apr 2004

Lewis Sarah J, Cherry Nicola M, Niven Robert McL, Barber Phillip V, Povey Andrew C

Abstract excerpt

N7-Methylguanine (N7-MeG) DNA adducts are markers of human exposure to methylating agents including tobacco-specific nitrosamines (TSNAs). Repair of this adduct is poor, so levels in lung tissue should reflect variation in both intensity of exposure and in metabolism. N7-MeG adducts in lung DNA f...

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Topics

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Share to Bronchoalveolar Lavage Fluid
Share to Chromatography, High Pressure Liquid
Share to Deoxyguanine Nucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Adducts

Share to Glutathione Transferase

Share to Guanine

Share to Phosphorus Radioisotopes

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Source

Identifiers

PMID: 15066569
DOI: 10.1016/j.mrgentox.2003.11.011

Genes

GSTM1
GSTT1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15066569-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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