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Article

Modification of urinary N7-methylguanine excretion in smokers by glutathione-S-transferase M1 polymorphism.

Toxicology - 16 Jun 2009

Lin I-Hsin, Chao Mu-Rong, Hu Chiung-Wen, Ho Ming-Lin, Huang Jo-Yun, Lee Hong-Shen, Chen Chun-Chieh, Wong Ruey-Hong

Abstract excerpt

Tobacco smoke contains many carcinogens which can lead to DNA methylation. Glutathione-S-transferases (GSTs) are detoxifying enzymes, and the effects of the genes GSTM1, GSTT1, and GSTP1 on cigarette smoke-induced methylated adducts have not been elucidated. Therefore, we investigated the associa...

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Source

Identifiers

PMID: 19464563
DOI: 10.1016/j.tox.2009.02.015

Genes

GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19464563-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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