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Article

Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study.

Free radical biology & medicine - 1 Jan 2012

Loft Steffen, Svoboda Peter, Kawai Kazuaki, Kasai Hiroshi, Sørensen Mette, Tjønneland Anne, Vogel Ulla, Møller Peter, Overvad Kim, Raaschou-Nielsen Ole

Abstract excerpt

Oxidative damage to guanine (8-oxoGua) is one of the most abundant lesions induced by oxidative stress and documented mutagenic. 8-Oxoguanine DNA glycosylase 1 (OGG1) removes 8-oxoGua from DNA by excision. The urinary excretion of 8-oxoGua is a biomarker of exposure, reflecting the rate of damage in the steady state. The aim of this study was to investigate urinary 8-oxoGua as a risk factor for lung cancer. In a...

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Source

Identifiers

PMID: 22044660
DOI: 10.1016/j.freeradbiomed.2011.10.439

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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