Article
Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.
Clinical and experimental immunology - 1 Sept 2007
Veltkamp M, Wijnen P A H M, van Moorsel C H M, Rijkers G T, Ruven H J T, Heron M, Bekers O, Claessen A M E, Drent M, van den Bosch J M M, Grutters J C
Abstract excerpt
The intracellular pathogens Propionibacterium acnes and Mycobacterium tuberculosis have been leading suspects as the cause of sarcoidosis, a systemic disorder characterized by the formation of non-caseating granulomas. Toll-like receptor (TLR) 2 is important in the innate immune response against both pathogens, and is therefore of interest in sarcoidosis research. In the present study, three single nucleotide...
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