Article
Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.
Molecular vision - 15 Mar 2011
Sato Mayuki, Kawagoe Tatsukata, Meguro Akira, Ota Masao, Katsuyama Yoshihiko, Ishihara Mami, Namba Kenichi, Kitaichi Nobuyoshi, Morimoto Shin-ichiro, Kaburaki Toshikatsu, Ando Yasutaka, Takenaka Shinobu, Ohno Shigeaki, Inoko Hidetoshi, Mizuki Nobuhisa
Abstract excerpt
PURPOSE: Sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas, with varied clinical manifestations. The common etiology of sarcoidosis is uncertain, but it is thought to be triggered by an exogenous antigenic stimulus, such as some bacterial proteins. Toll-like receptors (TLRs) recognize microbial components and elicit innate as well as adaptive immune...
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