Article
Role of genetic variants of Vitamin D receptor, Toll-like receptor 2 and Toll-like receptor 4 in extrapulmonary tuberculosis.
Microbial pathogenesis - 1 Jul 2021
Wani Bilal Ahmad, Shehjar Faheem, Shah Sonaullah, Koul Ajaz, Yusuf Adfar, Farooq Muzamil, Mir Mohmad Iqbal, Singh Rajni, Afroze Dil
Abstract excerpt
BACKGROUND: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB). Vitamin D deficiency and vitamin D receptor (VDR) gene abnormalities confer susceptibility to tuberculosis. Toll-like receptors (TLRs), such as TLR-2, are also important mediators of inflammatory response against Mycobacterium tuberculosis. We evaluated VDR, TLR-2 and TLR-4 gene polymorphisms in patients with...
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