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Article

Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.

Tissue antigens - 1 Jan 2012

Veltkamp M, van Moorsel C H M, Rijkers G T, Ruven H J T, Grutters J C

Abstract excerpt

Sarcoidosis is an inflammatory disease of unknown etiology. Various microorganisms have been proposed as etiologic agent suggesting a role for pattern-recognition receptors such as Toll-like receptors (TLRs) in disease pathogenesis, with a special interest in TLR-2. TLR-10, TLR-1, and TLR-6 act as co-receptors for TLR-2 and the genes encoding these receptors are located in a gene cluster on chromosome 4. The aim...

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Source

Identifiers

PMID: 22150367
DOI: 10.1111/j.1399-0039.2011.01808.x

Genes

TLR1
TLR10
TLR6

Provenance

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