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Article

Toll-like receptor (TLR) 4 polymorphisms are associated with a chronic course of sarcoidosis.

Clinical and experimental immunology - 1 Mar 2006

Pabst S, Baumgarten G, Stremmel A, Lennarz M, Knüfermann P, Gillissen A, Vetter H, Grohé C

Abstract excerpt

The aetiology of sarcoidosis, an inflammatory granulomatous multi-system disorder, is unclear. It is thought to be the product of an unknown exogenous antigenic stimulus and an endogenous genetic susceptibility. Toll-like receptors (TLR) are signal molecules essential for the cellular response to bacterial cell wall components. Lipopolysaccharide (LPS), for example, binds to TLR 4. Two different polymorphisms for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16487240
DOI: 10.1111/j.1365-2249.2006.03008.x
PMCID: PMC1809614

Genes

TLR4

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