Article
Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.
PloS one - 1 Jan 2014
Dayal Sanjana, Blokhin Ilya O, Erger Rochelle A, Jensen Melissa, Arning Erland, Stevens Jeff W, Bottiglieri Teodoro, Faraci Frank M, Lentz Steven R
Abstract excerpt
Diet-induced hyperhomocysteinemia produces endothelial and cardiac dysfunction and promotes thrombosis through a mechanism proposed to involve oxidative stress. Inducible nitric oxide synthase (iNOS) is upregulated in hyperhomocysteinemia and can generate superoxide. We therefore tested the hypothesis that iNOS mediates the adverse oxidative, vascular, thrombotic, and cardiac effects of hyperhomocysteinemia. Mice...
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