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Article

Osterix, a Transcription Factor for Osteoblast Differentiation, Mediates Antitumor Activity in Murine Osteosarcoma

15 Feb 2005

Abstract excerpt

Osterix is a novel zinc finger-containing transcription factor that is essential for osteoblast differentiation and bone formation. We hypothesized that osterix might have a role in osteosarcoma tumor growth and metastasis. Northern blot analysis showed that the mRNA level of osterix was decreased in two mouse osteosarcoma cell lines compared with its level in normal mouse osteoblasts. Osterix expression was also...

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PMID: 15734992
DOI: 10.1158/0008-5472.can-04-2128

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Osterix, a Transcription Factor for Osteoblast Differentiation, Mediates Antitumor Activity in Murine OsteosarcomaPMID 15734992Read ↗

Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancerSemantic proximity Read ↗

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone FormationSemantic proximity Read ↗

Transcriptional Regulation of Vascular Endothelial Growth Factor (VEGF) by Osteoblast-specific Transcription Factor Osterix (Osx) in OsteoblastsSemantic proximity Read ↗

RUNX2 and OsteosarcomaSemantic proximity Read ↗

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone FormationSemantic proximity Read ↗

Osteoblast differentiation in vitro and in vivo promoted by OsterixSemantic proximity Read ↗

The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cellsSemantic proximity Read ↗

Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossificationSemantic proximity Read ↗

The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.Semantic proximity Read ↗

Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix.Semantic proximity Read ↗

Genetic and molecular control of osterix in skeletal formation.Semantic proximity Read ↗

NELL-1, an Osteoinductive Factor, Is a Direct Transcriptional Target of OsterixSemantic proximity Read ↗

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