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Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx

15 Jun 2010

Abstract excerpt

Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling proteins. Osx (also known as Sp7) is the only osteoblast-specific transcriptional factor identified so far which is required for osteoblast differentiation and...

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PMID: 20550694
DOI: 10.1186/1749-799x-5-37

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