Article
Frequency of carriers of 8.1 ancestral haplotype and its fragments in two Caucasian populations.
Immunological investigations - 1 Jan 2007
Kiszel Petra, Kovács Margit, Szalai Csaba, Yang Yan, Pozsonyi Eva, Blaskó Bernadett, Laki Judit, Prohászka Zoltán, Fazakas Adám, Pánczél Pál, Hosszúfalusi Nóra, Rajczy Katalin, Wu Yee-Ling, Chung Erwin K, Zhou Bi, Blanchong Carol A, Vatay Agnes, Yu C Yung, Füst G
Abstract excerpt
Within the human MHC region larger stretches of conserved DNA, called conserved ancestral haplotypes exist. However, many MHC haplotypes contain only fragments of an ancestral haplotype. Little is known, however, on relative distribution of the ancestral haplotypes to their fragments. Therefore we determined the frequency of carriers of the whole ancestral haplotype 8.1 (AH8.1) and its fragments in 127 healthy...
Topics
- Alleles
- Child
- Diabetes Mellitus, Type 1
- Female
- Gene Frequency
- Haplotypes
- Humans
- Linkage Disequilibrium
- Major Histocompatibility Complex
- Male