Article
The HLA 8.1 ancestral haplotype is strongly linked to the C allele of -429T>C promoter polymorphism of receptor of the advanced glycation endproduct (RAGE) gene. Haplotype-independent association of the -429C allele with high hemoglobinA1C levels in diabetic patients.
Molecular immunology - 1 Jan 2007
Laki Judit, Kiszel Petra, Vatay Agnes, Blaskó Bernadett, Kovács Margit, Körner Anna, Madácsy László, Blatniczky László, Almássy Zsuzsa, Szalai Csaba, Rajczy Katalin, Pozsonyi Eva, Karádi István, Fazakas Adám, Hosszúfalusi Nóra, Pánczél Pál, Arason Gudmundur J, Wu Yee-Ling, Zhou Bi, Yang Yan, Yu C-Yung, Füst George
Abstract excerpt
Previously we reported on strong linkage disequilibrium (LD) between the mono-S-C4B-RCCX module (mono-S) and the TNF2 allele (both known constituents of the 8.1 ancestral haplotype (8.1 AH)) in two Caucasian populations. The gene for the receptor of advanced glycation endproducts (RAGE) is encoded between the RCCX module and the HLA class II genes in the central MHC region. In order to assess the relationship...
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