Article
Genetic control of immune response in carriers of the 8.1 ancestral haplotype: correlation with levels of IgG subclasses: its relevance in the pathogenesis of autoimmune diseases.
Annals of the New York Academy of Sciences - 1 Sept 2007
Candore Giuseppina, Campagna Anna Maria, Cuppari Irene, Di Carlo Daniele, Mineo Claudia, Caruso Calogero
Abstract excerpt
Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and the lack of C4A protein. So AH 8.1 modifies immune response in many ways. In this study we...
Topics
- Adult
- Autoimmune Diseases
- Female
- Genetic Predisposition to Disease
- HLA-B8 Antigen
- HLA-DR3 Antigen
- Haplotypes
- Heterozygote
- Humans
- Immunoglobulin G
- Male
- Middle Aged