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Article

Ancestral haplotypes: conserved population MHC haplotypes.

Human immunology - 1 Aug 1992

Degli-Esposti M A, Leaver A L, Christiansen F T, Witt C S, Abraham L J, Dawkins R L

Abstract excerpt

We describe here a number of Caucasoid MHC haplotypes that extend from HLA-B to DR and that have been conserved en bloc. These haplotypes and recombinants between any two of them account for 73% of unselected haplotypes in our Caucasoid population. The existence of ancestral haplotypes implies conservation of large chromosomal segments. Irrespective of the mechanisms involved in preservation of ancestral...

Topics

Alleles
Genetic Markers
Haplotypes
Humans
Major Histocompatibility Complex
Polymorphism, Genetic
Recombination, Genetic
White People

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1464552
DOI: 10.1016/0198-8859(92)90023-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1464552-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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