Article
Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameters of healthy carriers of the haplotype.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Sept 2003
Candore Giuseppina, Modica Maria Assunta, Lio Domenico, Colonna-Romano Giuseppina, Listì Florinda, Grimaldi Maria Paola, Russo Mariangela, Triolo Giovanni, Accardo-Palumbo Antonia, Cuccia Maria Clara, Caruso Calogero
Abstract excerpt
Subjects with certain HLA alleles have a higher risk of specific autoimmune diseases than those without these alleles. The 8.1 ancestral haplotype (AH) is a common Caucasoid haplotype carried by most people who type for HLA-B8,DR3. It is unique in its association with a wide range of immunopathol...
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