Article
Haplotypic polymorphisms of the TNFB gene.
Immunogenetics - 1 Jan 1991
Abraham L J, Du D C, Zahedi K, Dawkins R L, Whitehead A S
Abstract excerpt
The TNFB genes from two major histocompatibility complex (MHC) ancestral haplotypes have been compared. The genes carried by the ancestral haplotypes 8.1 (A1,B8,BfS,C4AQ0, C4B1,DR3) and 57.1 (A1, B57. BfS, C4A6, C4B1, DR7) were cloned and sequenced to determine the degree of polymorphism. In this report we show that the respective TNF genes are allelic and have unique nucleotide sequences. The data demonstrate...
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