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Article

Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene.

Archives of toxicology - 1 Sept 2008

Lankisch Tim O, Gillman Tracey C, Erichsen Thomas J, Ehmer Ursula, Kalthoff Sandra, Freiberg Nicole, Munzel Peter A, Manns Michael P, Strassburg Christian P

Abstract excerpt

UDP-glucuronosyltransferases contribute to the detoxification of drugs by forming water soluble beta-D-glucopyranosiduronic acids. The human UGT1A3 protein catalyzes the glucuronidation of estrogens, bile acids and xenobiotics including non-steroidal anti-inflammatory drugs and lipid lowering drugs. Regulation of UGT1A3 by xenobiotic response elements is likely, but the responsible elements are yet...

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PMID: 18677463
DOI: 10.1007/s00204-008-0347-1

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