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Article

Liver-Specific pRB Loss Results in Ectopic Cell Cycle Entry and Aberrant Ploidy

1 Jun 2005

Abstract excerpt

The liver exhibits an exquisitely controlled cell cycle, wherein hepatocytes are maintained in quiescence until stimulated to proliferate. The retinoblastoma tumor suppressor, pRB, plays a central role in proliferative control by inhibiting inappropriate cell cycle entry. In many cases, liver cancer arises due to aberrant cycles of proliferation, and correspondingly, pRB is functionally inactivated in the...

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PMID: 15930274
DOI: 10.1158/0008-5472.can-04-4221

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