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Article

Variant t(2;11)(p11.2;q13) without IGK involvement in a case of mantle cell lymphoma.

Cancer genetics and cytogenetics - 1 Jun 2007

Woroniecka Renata, Grygalewicz Beata, Pienkowska-Grela Barbara, Rymkiewicz Grzegorz, Konecki Robert, Swoboda Pawel, Janik Przemyslaw

Abstract excerpt

Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation, which leads to overexpression of the cyclin D1 (CCND1) gene. This translocation is observed in almost all cases of MCL. In this alteration, the involvement of immunoglobulin heavy chain (IGH) locus plays a key role in the activation of the CCND1 oncogene. Translocations affecting IGH loci are mostly prevalent in B-cell lymphomas,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17556072
DOI: 10.1016/j.cancergencyto.2007.02.012

Genes

IGK
CCND1
IGH
IGL
REL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variant t(2;11)(p11.2;q13) without IGK involvement in a case of mantle cell lymphoma.PMID 17556072Read ↗

Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma.Semantic proximity Read ↗

Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.Semantic proximity Read ↗

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Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes.Semantic proximity Read ↗

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Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma.Semantic proximity Read ↗

Diagnostic utility of fluorescence <i>in situ</i> hybridization in mantle‐cell lymphomaSemantic proximity Read ↗

t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform.Semantic proximity Read ↗

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Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomasSemantic proximity Read ↗

Large-scale nuclear remodeling and transcriptional deregulation occur on both derivative chromosomes after Mantle Cell Lymphoma chromosomal translocationSemantic proximity Read ↗

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