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CCND2 rearrangements are the most frequent genetic events in cyclin D1− mantle cell lymphoma

20 Dec 2012

Abstract excerpt

Cyclin D1(-) mantle cell lymphomas (MCLs) are not well characterized, in part because of the difficulties in their recognition. SOX11 has been identified recently as a reliable biomarker of MCL that is also expressed in the cyclin D1(-) variant. We investigated 40 lymphomas with MCL morphology and immunophenotype that were negative for cyclin D1 expression/t(11;14)(q13;q32) but positive for SOX11. These tumors...

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PMID: 23255553
DOI: 10.1182/blood-2012-08-452284

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