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Article

Type VI secretion is a major virulence determinant in Burkholderia mallei

1 Jun 2007

Abstract excerpt

Burkholderia mallei is a host-adapted pathogen and a category B biothreat agent. Although the B. mallei VirAG two-component regulatory system is required for virulence in hamsters, the virulence genes it regulates are unknown. Here we show with expression profiling that overexpression of virAG resulted in transcriptional activation of approximately 60 genes, including some involved in capsule production,...

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PMID: 17555434
DOI: 10.1111/j.1365-2958.2007.05734.x

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