Article
A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins.
mBio - 22 Oct 2019
D'Gama Jonathan D, Ma Zhe, Zhang Hailong, Liu Xu, Fan Hongjie, Morris Ellen Ruth A, Cohen Noah D, Cywes-Bentley Colette, Pier Gerald B, Waldor Matthew K
Abstract excerpt
Streptococcus equi subspecies zooepidemicus (SEZ) are group C streptococci that are important pathogens of economically valuable animals such as horses and pigs. Here, we found that many SEZ isolates bind to a monoclonal antibody that recognizes poly-N-acetylglucosamine (PNAG), a polymer that is found as a surface capsule-like structure on diverse microbes. A fluorescence-activated cell sorting-based transposon...
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