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Article

Multimer formation by FKBP-12: roles for cysteine 23 and phenylalanine 36.

Journal of peptide science : an official publication of the European Peptide Society - 1 Jul 2007

Schories Barbara, Nelson Thomas E, Sane David C

Abstract excerpt

FKBP-12 mediates the immunosuppressive actions of FK506 and rapamycin, and modulates the activities of the ryanodine, IP3 and type 1 TGF-ss receptors. Additionally, FKBP-12 possesses cis-trans peptidylprolyl isomerase (rotamase) activity. We have discovered that recombinant FKBP-12 readily forms a dimer and a small amount of trimer under nonreducing conditions. A mutant with substitution at the sole cysteine...

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Source

Identifiers

PMID: 17554808
DOI: 10.1002/psc.871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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