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Article

N-terminal region of FKBP12 is essential for binding to the skeletal ryanodine receptor.

The Journal of biological chemistry - 18 Jun 2004

Lee Eun Hui, Rho Seong-Hwan, Kwon Soon-Jae, Eom Soo Hyun, Allen Paul D, Kim Do Han

Abstract excerpt

It is known that the two types of FK506-binding proteins FKBP12 and FKBP12.6 are tightly associated with the skeletal (RyR1) and cardiac ryanodine receptors (RyR2), respectively, and their interactions are important for channel functions of the RyR. In the case of cardiac muscle, three amino acid...

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Identifiers

PMID: 15033987
DOI: 10.1074/jbc.M309574200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15033987-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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