Article
Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization.
Biochemical and biophysical research communications - 20 May 2011
Feng Miao, Gu Chao, Ma Shikui, Wang Ying, Liu Huijuan, Han Ruifang, Gao Junfei, Long Yi, Mi Huaifeng
Abstract excerpt
FK506-binding proteins (FKBPs) are cellular receptors for the immunosuppressant FK506 and rapamycin. They belong to the ubiquitous peptidyl-prolyl cis/trans isomerases (PPIases) family, which can catalyze the cis/trans isomerization of peptidyl-prolyl bond in peptides and proteins. In previous work, we revealed that mouse FKBP23 binds immunoglobulin binding protein (BiP), the major heat shock protein (Hsp) 70...
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