Article
Determining the roles of a conserved tyrosine residue in a Mip-like peptidyl-prolyl cis-trans isomerase.
International journal of biological macromolecules - 1 Jun 2016
Polley Soumitra, Chakravarty Devlina, Chakrabarti Gopal, Sau Subrata
Abstract excerpt
The FKBP22 and the related peptidyl-prolyl cis-trans isomerases dimerize using their N-terminal domains. Conversely, their C-terminal domains possess both the substrate and inhibitor binding sites. To delineate the roles of a conserved Tyr residue at their N-terminal domains, we have studied a FKBP22 mutant that carries an Ala in place of the conserved Tyr at position 15. We have demonstrated that the Tyr 15 of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.