Article
Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1998
Barent R L, Nair S C, Carr D C, Ruan Y, Rimerman R A, Fulton J, Zhang Y, Smith D F
Abstract excerpt
FKBP51, FKBP52, and Cyp40 bind competitively to Hsp90 through their respective tetratricopeptide repeat (TPR) domains, and any one of the three immunophilins can be isolated in mature steroid receptor complexes. During cell-free assembly reactions, FKBP51 associates preferentially with progestero...
Topics
- Amino Acid Sequence
- Binding Sites
- Carrier Proteins
- DNA-Binding Proteins
- HSP90 Heat-Shock Proteins
- Heat-Shock Proteins
- Molecular Sequence Data
- Mutation
- Peptidylprolyl Isomerase
- Receptors, Progesterone
- Recombinant Proteins
- Tacrolimus Binding Proteins