Article
The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jun 2007
Aubrey Karin R, Rossi Francesco M, Ruivo Raquel, Alboni Silvia, Bellenchi Gian Carlo, Le Goff Anne, Gasnier Bruno, Supplisson Stéphane
Abstract excerpt
The mechanisms that specify the vesicular phenotype of inhibitory interneurons in vertebrates are poorly understood because the two main inhibitory transmitters, glycine and GABA, share the same vesicular inhibitory amino acid transporter (VIAAT) and are both present in neurons during postnatal development. We have expressed VIAAT and the plasmalemmal transporters for glycine and GABA in a neuroendocrine cell...
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